The Angers lab studies the molecular mechanisms underlying the inter and intracellular signal transduction events controlled by the Wnt and Hedgehog families of secreted Growth Factors. We use an integrative approach combining proteomic and genomic tools to identify novel components in these signalling pathways and study their normal functions during development and tissue homeostasis in adults but also how these molecules become dysregulated in human diseases such as cancer. Using CRISPR-Cas9 screening approaches, the lab is also probing the genetic wiring of high fatality cancers, such as Glioblastoma and pancreatic ductal adenocarcinoma to identify novel therapeutic targets.
