2025
- C1q limits cystoid edema by maintaining basal β-catenin-dependent signaling and blood-retina barrier function.JCI insight
- Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils.Communications biology
- C1q limits cystoid edema by maintaining basal beta-catenin-dependent signaling and blood-retina barrier function.bioRxiv : the preprint server for biology
- The ORB2 RNA-binding protein represses translation of its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding 'ZZ' domain.bioRxiv : the preprint server for biology
- Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma.Cell reports. Medicine
- Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation.Cancer research
- PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.Nucleic acids research
- Mechanistic insights into Wnt-β-catenin pathway activation and signal transduction.Nature reviews. Molecular cell biology
- Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation.Stem cell reports
- Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs.Molecular systems biology
2024
- mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation.Cell reports
- The WAVE regulatory complex interacts with Boc and is required for Shh-mediated axon guidance.iScience
- Identification of VISTA regulators in macrophages mediating cancer cell survival.Science advances
- TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells.Cell death discovery
- Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation.bioRxiv : the preprint server for biology
- Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities.Cancer research
- Get your receptors in a knot with new Wnt signaling agonists.Cell chemical biology
- ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.Nature communications
- Post-transcriptional regulatory pre-complex assembly drives timely cell-state transitions during differentiation.bioRxiv : the preprint server for biology
- Phenotypic targeting using magnetic nanoparticles for rapid characterization of cellular proliferation regulators.Science advances
- Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification.Development (Cambridge, England)
2023
- The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma.Cell death discovery
- CRISPR Screening in Tandem with Targeted mtDNA Damage Reveals WRNIP1 Essentiality.ACS chemical biology
- FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe.Cancer research communications
- Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting.Nature biomedical engineering
- CRISPR Screening in Tandem with Targeted mtDNA Damage Reveals WRNIP1 Essentiality.bioRxiv : the preprint server for biology
- A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response.iScience
- Relative Biological Effectiveness (RBE) of [Nuclear medicine and biology
- Targeted alveolar regeneration with Frizzled-specific agonists.Cell
- Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling.Nucleic acids research
- Modulation of Wnt-β-catenin signaling with antibodies: therapeutic opportunities and challenges.Trends in pharmacological sciences
- Efficient Delivery of Biological Cargos into Primary Cells by Electrodeposited Nanoneedles via Cell-Cycle-Dependent Endocytosis.Nano letters
- Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes.Science advances
- Wnt signaling in stem cells during development and cell lineage specification.Current topics in developmental biology
2022
- nuPRISM: Microfluidic Genome-Wide Phenotypic Screening Platform for Cellular Nuclei.ACS central science
- Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964.Structure (London, England : 1993)
- CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.Nature communications
- SCFEMBO reports
- Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b.Cell reports. Medicine
- Genome-wide in vivo screen of circulating tumor cells identifiesScience advances
- Frizzled does not get bent out of shape by Wnt.Science signaling
- Identification of Drug Resistance Mechanisms Using Genome-Wide CRISPR-Cas9 Screens.Methods in molecular biology (Clifton, N.J.)
- Nanoparticle Amplification Labeling for High-Performance Magnetic Cell Sorting.Nano letters
- The F-box protein Bard (CG14317) targets the Smaug RNA-binding protein for destruction during the Drosophila maternal-to-zygotic transition.Genetics
2021
- Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity.Nature cancer
- Rapid On-Cell Selection of High-Performance Human Antibodies.ACS central science
- A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.EMBO molecular medicine
- Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors.EMBO molecular medicine
- The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.Oncogene
- Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival.eLife
2020
- Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Nature communications
- Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.Proceedings of the National Academy of Sciences of the United States of America
- Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition.Cell reports
- Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Cell
- Nanostructured Architectures Promote the Mesenchymal-Epithelial Transition for Invasive Cells.ACS nano
- The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs.Cell reports
- Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.Developmental cell
- IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.The Journal of cell biology
2019
- Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.Cell
- High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.Nature biomedical engineering
- Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.eLife
- Identifying chemogenetic interactions from CRISPR screens with drugZ.Genome medicine
- Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.Cell reports
- Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.Proceedings of the National Academy of Sciences of the United States of America
- Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells.Genes & development
- Agonist-induced desensitisation of βBritish journal of pharmacology
- ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development.Nucleic acids research
2018
- Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.Developmental cell
- Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction.Nano letters
- A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties.mAbs
- CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.Nature
- Wnt signaling in development and tissue homeostasis.Development (Cambridge, England)
- Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.Nature chemical biology
- A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.Nature chemical biology
- High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.Molecular cell
2017
- Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.Nature medicine
- ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.Cell stem cell
- ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.Cell stem cell
- Separating the Anti-Inflammatory and Diabetogenic Effects of Glucocorticoids Through LXRβ Antagonism.Endocrinology
- Systematic protein-protein interaction mapping for clinically relevant human GPCRs.Molecular systems biology
2016
- Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.Nature medicine
- Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.Journal of cell science
- Identification of Novel Smoothened Ligands Using Structure-Based Docking.PloS one
- Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.Proceedings of the National Academy of Sciences of the United States of America
- Role of Spinophilin in Group I Metabotropic Glutamate Receptor Endocytosis, Signaling, and Synaptic Plasticity.The Journal of biological chemistry
- PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2.Developmental cell
- Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.Nature
- SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.Developmental cell
- YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.Oncogene
2015
- High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Cell
- A Par-1-Par-3-Centrosome Cell Polarity Pathway and Its Tuning for Isotropic Cell Adhesion.Current biology : CB
- The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity.PloS one
- Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.Cellular signalling
- BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.Molecular & cellular proteomics : MCP
- Ca(2+)/calmodulin-dependent protein kinase II interacts with group I metabotropic glutamate and facilitates receptor endocytosis and ERK1/2 signaling: role of β-amyloid.Molecular brain
- Tandem affinity purification to identify cytosolic and nuclear gβγ-interacting proteins.Methods in molecular biology (Clifton, N.J.)
2014
- Stepping stone: a cytohesin adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo.Molecular biology of the cell
- The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.PloS one
- The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.Science signaling
- Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development.Developmental biology
- Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.Molecular & cellular proteomics : MCP
- New insights in the regulation of Rab GTPases by G protein-coupled receptors.Small GTPases
2013
- Ubiquitylation and activation of a Rab GTPase is promoted by a β₂AR-HACE1 complex.Journal of cell science
- Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.Molecular endocrinology (Baltimore, Md.)
- Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell carcinoma.Oncogene
- The human PDZome: a gateway to PSD95-Disc large-zonula occludens (PDZ)-mediated functions.Molecular & cellular proteomics : MCP
- Emerging non-canonical functions for heterotrimeric G proteins in cellular signaling.Journal of receptor and signal transduction research
- A novel assay for measurement of membrane-protein surface expression using a β-lactamase.Traffic (Copenhagen, Denmark)
- Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development.Development (Cambridge, England)
2012
- KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.The Journal of cell biology
- Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.PloS one
- Radil controls neutrophil adhesion and motility through β2-integrin activation.Molecular biology of the cell
- A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.PLoS pathogens
2011
- A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression.Oncogene
- Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.Molecular and cellular biology
- Calcium-sensing receptor modulates cell adhesion and migration via integrins.The Journal of biological chemistry
- Tandem affinity purification and identification of heterotrimeric g protein-associated proteins.Methods in molecular biology (Clifton, N.J.)
- Gli proteins in development and disease.Annual review of cell and developmental biology
- The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling.Molecular and cellular biology
2010
- Oligomeric size of the m2 muscarinic receptor in live cells as determined by quantitative fluorescence resonance energy transfer.The Journal of biological chemistry
- G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil.The Journal of biological chemistry
2009
- YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation.Genes & development
- Glutamate transporter coupling to Na,K-ATPase.The Journal of neuroscience : the official journal of the Society for Neuroscience
- Proximal events in Wnt signal transduction.Nature reviews. Molecular cell biology
- Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.PloS one
2008
- Proteomic analyses of protein complexes in the Wnt pathway.Methods in molecular biology (Clifton, N.J.)
- New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening.Science signaling
2007
- [The tumor suppressor gene WTX, mutated in Wilms tumours, is a member of the beta-catenin destruction complex].Medecine sciences : M/S
- Recovery of oligomers and cooperativity when monomers of the M2 muscarinic cholinergic receptor are reconstituted into phospholipid vesicles.Biochemistry
- Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.Science (New York, N.Y.)
- [KLHL12/Cullin-3 is a new E3 ubiquitin ligase negatively regulating the Wnt pathway].Medecine sciences : M/S
2006
- Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.Nature
- The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation.Nature cell biology
2005
- An aplysia dopamine1-like receptor: molecular and functional characterization.Journal of neurochemistry
2004
- Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting.The Journal of biological chemistry
2003
- Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors.Proceedings of the National Academy of Sciences of the United States of America
2002
- The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS).Journal of receptor and signal transduction research
- Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer.The Journal of biological chemistry
- Constitutive agonist-independent CCR5 oligomerization and antibody-mediated clustering occurring at physiological levels of receptors.The Journal of biological chemistry
- Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer.The Journal of biological chemistry
- Functional characterization of a novel serotonin receptor (5-HTap2) expressed in the CNS of Aplysia californica.Journal of neurochemistry
- Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function.Annual review of pharmacology and toxicology
2001
- Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells.Life sciences
2000
- Reply: beyond receptor dimerization.Trends in pharmacological sciences
- Functional significance of oligomerization of G-protein-coupled receptors.Trends in endocrinology and metabolism: TEM
- Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants.The Journal of clinical investigation
- Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET).Proceedings of the National Academy of Sciences of the United States of America
1999
- Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis.The Journal of biological chemistry